Establishment of a new human acute monocytic leukemia cell line TZ-1 with t(1;11)(p32;q23) and fusion gene MLL-EPS15 (2024)

1. Rowley JD . The role of chromosome translocation in leukemogenesis. Semin Hematol 1999; 36: 59–72.

   CAS PubMed Google Scholar

2. Sorensen PHB, Chen CS, Smith FO, Arthur DC, Domer PH, Kersey JH et al. Molecular rearrangements of the MLL gene are present in most cases of infant acute myeloid leukemia and are strongly correlated with monocytic or myelomonocytic phenotypes. J Clin Invest 1994; 93: 429–437.

   Article CAS PubMed PubMed Central Google Scholar

3. Rubnitz JE, Behm FG, Downing JR . 11q23 rearrangements in acute leukemia. Leukemia 1996; 10: 74–82.

   CAS PubMed Google Scholar

4. Haferlach T, Schoch C, Schnittger S, Kern W, Loffler H, Hiddemann W . Distinct genetic patterns can be identified in acute monoblastic and acute monocytic leukemia (FAB AML M5a and M5b): a study of 124 patients. Br J Haematol 1996; 93: 966–972.

   Article Google Scholar

5. Bloomfield CD, Archer KJ, Mrozek K, Lillington DM, Kaneko Y, Head DR et al. 11q23 balanced chromosome aberrations in treatment-related myelodysplastic syndromes and acute leukemia: report from an international workshop. Genes Chromosomes Cancer 2002; 33: 362–378.

   Article PubMed Google Scholar

6. Drexler HG, Quentmeier H, MacLeod RAF . Malignant hematopoietic cell lines: in vitro models for the study of MLL gene alterations. Leukemia 2004; 18: 227–232.

   Article CAS PubMed Google Scholar

7. Jaffe ES, Harris NL, Stein H, Vardiman JW (eds). Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. IARC Press: Lyon, France, 2001.

   Google Scholar

8. Schoch C, Schnittger S, Klaus M, Kern W, Hiddemann W, Haferlach T . AML with 11q23/MLL abnormalities as defined by the WHO classification: incidence, partner chromosomes, FAB subtype, age distribution, and prognostic impact in an unselected series of 1897 cytogenetically analyzed AML cases. Blood 2003; 102: 2395–2402.

   Article CAS PubMed Google Scholar

9. Tsujioka T, Wada H, Yamamori S, Otsuki T, Suemori S, Sugihara T et al. MLL/EPS15 fusion in therapy-related early pre-B acute lymphoblastic leukemia with t(1;11) (p32;q23) translocation developing in the relapse phase of acute promyelocytic leukemia. Int J Hematol 2003; 78: 439–442.

   Article CAS PubMed Google Scholar

10. Bernard OA, Mauchauffe M, Mecucci C, Van den Berghe H, Berger R . A novel gene, EPS15, fused to HRX in t(1;11) (p32; q23), is not related to AF-4, AF-9 nor ENL. Oncogene 1994; 9: 1039–1045.

    CAS PubMed Google Scholar

11. Chen S, Xue Y, Zhang X, Wu Y, Pan J, Ceng J et al. A new human monocytic leukemia cell line SHI-1 with t(6;11)(q27;q23), p53 gene alterations and high tumorigenicity in nude mice. Haematologica 2005; 90: 766–775.

    CAS PubMed Google Scholar

12. Douet-Guilbert N, Morel F, Le Bris MJ, Herry A, Morice P, De Braekeleer M et al. Rearrangement of the MLL gene in acute myeloblastic leukemia: report of two rare translocations. Cancer Genet Cytogenet 2005; 157: 169–174.

    Article CAS PubMed Google Scholar

13. Harrison CJ, Cuneo A, Clark R, Johansson B, Lafa*ge-Pochitaloff M, Mugneret F, et al., on behalf of the European 11q23 Workshop participants. Ten novel 11q23 chromosomal partner sites. Leukemia 1998; 12: 811–822.

    Article CAS PubMed Google Scholar

14. Strehl S, Konig M, Mann G, Haas OA . Multiplex reverse transcriptase-polymerase chain reaction screening in childhood acute myeloblastic leukemia. Blood 2001; 97: 805–808.

    Article CAS PubMed Google Scholar

15. Secker-Walker LM, Moorman AV, Bain BJ, Mehta AB, on behalf of the EU Concerted Action 11q23 Workshop. Secondary acute leukemia and myeloblastic syndrome with 11q23 abnormalities. Leukemia 1998; 12: 840–844.

    Article CAS PubMed Google Scholar

16. Palka G, Calabrese G, Di Girolamo G, Stuppia L, Di Bartolomeo P, Torlontano G et al. Cytogenetic survey of 31 patients treated with bone marrow transplantation for acute nonlymphocytic and acute lymphoblastic leukemias. Cancer Genet Cytogenet 1991; 51: 223–233.

    Article CAS PubMed Google Scholar

17. Satake N, Maseki N, Nishiyama M, Kobayashi H, Sakurai M, Kaneko Y . Chromosome abnormalities and MLL rearrangements in acute myeloid leukemia in infants. Leukemia 1999; 13: 1013–1017.

    Article CAS PubMed Google Scholar

18. Fazioli F, Minichiello L, Matoskova B, Wong WT, Di Fiore PP . Eps15, a novel tyrosine kinase substrate, exhibits transforming activity. Mol Cell Biol 1993; 13: 5814–5828.

    Article CAS PubMed PubMed Central Google Scholar

19. Fazioli F, Wong WT, Ullrich SJ, Sakaguchi K, Appella E, Di Fiore PP . The ezrin-like family of tyrosine kinase substrates: receptor-specific pattern of tyrosine phosphorylation and relationship to malignant transformation. Oncogene 1994; 8: 1335–1345.

    Google Scholar

20. Wong WT, Kraus MH, Carlomagno F, Zelano A, Druck T, Di Fiorre PP et al. The human eps15 gene, encoding a tyrosine kinase substrate, is conserved in evolution and maps to 1p31–p32. Oncogene 1994; 9: 1591–1597.

    CAS PubMed Google Scholar

21. So CW, Lin M, Ayton PM, Chen EH, Cleary ML . Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias. Cancer Cell 2003; 4: 99–110.

    Article CAS PubMed Google Scholar

22. Ayton PM, Cleary ML . Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9. Genes Dev 2003; 17: 2298–2307.

    Article CAS PubMed PubMed Central Google Scholar

23. Milne TA, Martin ME, Brock HW, Slany RK, Hess JL . Leukemogenic MLL fusion proteins bind across a broad region of the Hoxa9 locus, promoting transcription and multiple histone modifications. Cancer Res 2005; 65: 11367–11374.

    Article CAS PubMed Google Scholar

Download references